Title : Mre11 and Exo1 contribute to the initiation and processivity of resection at meiotic double-strand breaks made independently of Spo11.

Pub. Date : 2011 Feb 7

PMID : 21146476






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Analysis of strains with different mutant alleles of MRE11 (mre11-58S and mre11-H125N) and deleted for EXO1 indicated that these two nucleases make significant contributions to repair of VDE-DSBs. vde-dsbs Rad2 family nuclease EXO1 Saccharomyces cerevisiae S288C
2 Physical analysis of single-stranded repair intermediates indicates that efficient initiation and processivity of resection at VDE-DSBs require both Mre11 and Exo1, with loss of function for either protein causing severe delay in resection. vde-dsbs Rad2 family nuclease EXO1 Saccharomyces cerevisiae S288C