Title : Association of an MDR1 gene (C3435T) polymorphism with acute leukemia in India.

Pub. Date : 2010

PMID : 21133625






1 Functional Relationships(s)
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1 The association of CC genotype with clinical variables in ALL indicated that the CC genotype with high expression might be eliminating antileukemic drugs (anthracyclines, Daunorubicin, Vincristeine, Mitoxanthrone) which are P-gp substrates, leading to lower intra cellular drug concentrations and a poor prognosis. Daunorubicin phosphoglycolate phosphatase Homo sapiens