Title : Phenotypic enhancement of thymidylate synthetase pathway inhibitors following ablation of Neil1 DNA glycosylase/lyase.

Pub. Date : 2010 Dec 15

PMID : 21131780






1 Functional Relationships(s)
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1 We observed specific ablation of the mixed function DNA glycosylase/lyase Neil1 phenotypically enhanced several inhibitors of thymidine biosynthesis, as well as cellular phenotypes downstream of gemcitabine, cytarabine and clofarabine exposure. Cytarabine nei like DNA glycosylase 1 Homo sapiens