Title : Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants.

Pub. Date : 2011 Jan 7

PMID : 21130737






1 Functional Relationships(s)
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1 Both Desipramine and FTY720 treatment reduced ASMase without significant inhibition of other lysosomal hydrolases but most hydrolases showed increased secretion (up to a 50% increase) providing more evidence of lysosomal disruption by these drugs. Desipramine sphingomyelin phosphodiesterase 1 Homo sapiens