Title : Loop 5-directed compounds inhibit chimeric kinesin-5 motors: implications for conserved allosteric mechanisms.

Pub. Date : 2011 Feb 25

PMID : 21127071






1 Functional Relationships(s)
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1 For example, S-trityl-l-cysteine (STC) and monastrol are HsEg5 inhibitors that bind to a surface pocket created by the L5 loop, but neither compound inhibits the Drosophila Kinesin-5 homologue (Klp61F). monastrol Kinesin-like protein at 61F Drosophila melanogaster