Pub. Date : 2011 Feb
PMID : 21120454
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine. | Desipramine | ETS transcription factor ERG | Homo sapiens |
| 2 | We found that desipramine reduced hERG currents by binding to a receptor site inside the channel pore. | Desipramine | ETS transcription factor ERG | Homo sapiens |
| 3 | Finally, desipramine triggered apoptosis in cells expressing hERG channels. | Desipramine | ETS transcription factor ERG | Homo sapiens |
| 4 | Desipramine exerts at least four different cellular effects: (1) direct hERG channel block, (2) acute reduction of hERG surface expression, (3) chronic disruption of hERG trafficking, and (4) induction of apoptosis. | Desipramine | ETS transcription factor ERG | Homo sapiens |
| 5 | Desipramine exerts at least four different cellular effects: (1) direct hERG channel block, (2) acute reduction of hERG surface expression, (3) chronic disruption of hERG trafficking, and (4) induction of apoptosis. | Desipramine | ETS transcription factor ERG | Homo sapiens |
| 6 | Desipramine exerts at least four different cellular effects: (1) direct hERG channel block, (2) acute reduction of hERG surface expression, (3) chronic disruption of hERG trafficking, and (4) induction of apoptosis. | Desipramine | ETS transcription factor ERG | Homo sapiens |