Title : The Hsp90 inhibitor IPI-504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP/Grp78.

Pub. Date : 2011 Jan 27

PMID : 21106982






1 Functional Relationships(s)
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1 In bortezomib-resistant cells, both BiP/Grp78 knockdown and cell pretreatment with the Hsp90 inhibitor of the ansamycin class, IPI-504, led to synergistic induction of apoptotic cell death when combined with bortezomib. Rifabutin heat shock protein family A (Hsp70) member 5 Homo sapiens