Title : Insulin activates epithelial sodium channel (ENaC) via phosphoinositide 3-kinase in mammalian taste receptor cells.

Pub. Date : 2011 Apr

PMID : 21106690






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In fungiform and vallate TRCs that exhibit functional ENaC currents (e.g., amiloride-sensitive Na(+) influx), insulin (5-20 nM) caused a significant increase in Na(+) influx at -80 mV (EC(50) = 7.53 nM). Amiloride sodium channel, nonvoltage-gated 1 alpha Mus musculus
2 Interestingly, these differences between groups were abolished when amiloride (100 muM) was added into NaCl solutions, suggesting that insulin was regulating ENaC. Amiloride sodium channel, nonvoltage-gated 1 alpha Mus musculus