Pub. Date : 2011 Feb
PMID : 21097524
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TNF/TNFR1 signaling mediates doxorubicin-induced diaphragm weakness. | Doxorubicin | tumor necrosis factor | Homo sapiens |
| 2 | Tumor necrosis factor-alpha (TNF), a proinflammatory cytokine that depresses diaphragm force, is elevated following doxorubicin chemotherapy. | Doxorubicin | tumor necrosis factor | Homo sapiens |
| 3 | Tumor necrosis factor-alpha (TNF), a proinflammatory cytokine that depresses diaphragm force, is elevated following doxorubicin chemotherapy. | Doxorubicin | tumor necrosis factor | Homo sapiens |
| 4 | These findings lead us to hypothesize that TNF/TNFR1 signaling mediates doxorubicin-induced diaphragm muscle weakness. | Doxorubicin | tumor necrosis factor | Homo sapiens |
| 5 | Etanercept, a soluble TNF receptor, and TNFR1 deficiency protected against the depression in diaphragm-specific force caused by doxorubicin. | Doxorubicin | tumor necrosis factor | Homo sapiens |
| 6 | These results suggest that doxorubicin increases diaphragm sensitivity to TNF by upregulating TNFR1, thereby causing respiratory muscle weakness. | Doxorubicin | tumor necrosis factor | Homo sapiens |