Pub. Date : 2011 May 15
PMID : 21095016
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Association of DRD2 and ANKK1 polymorphisms with prolactin increase in olanzapine-treated women. | Olanzapine | prolactin | Homo sapiens |
| 2 | Single nucleotide polymorphisms (SNPs), rs2734842(C), rs6275(T), and rs6279(C) located within DRD2, have been shown to be associated with prolactin increase in olanzapine/fluoxetine combination (OFC)-treated women. | Olanzapine | prolactin | Homo sapiens |
| 3 | An ANCOVA was used to test whether change from baseline in the natural log of prolactin concentration (ln[prolactin]) was associated with SNPs in the pooled olanzapine studies. | Olanzapine | prolactin | Homo sapiens |
| 4 | Negative strand alleles rs2734842(C), rs6275(T), and rs6279(C) were significantly associated with increased prolactin in olanzapine-treated women, replicating previous results. | Olanzapine | prolactin | Homo sapiens |
| 5 | These SNPs also showed moderate association with increased prolactin in olanzapine-treated and OFC-treated women in the meta-analysis, as did rs4938016, rs2734848, rs2734841, rs1124493, and rs1076562. | Olanzapine | prolactin | Homo sapiens |