Pub. Date : 2010 Jan
PMID : 21072376
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibitory effect of CuSO4 on alpha-glucosidase activity in ddY mice. | Copper Sulfate | sucrase isomaltase (alpha-glucosidase) | Mus musculus |
| 2 | CuSO4 and ZnSO4 exhibited a high alpha-glucosidase inhibitory effect in vitro. | Copper Sulfate | sucrase isomaltase (alpha-glucosidase) | Mus musculus |
| 3 | The IC(50) values of CuSO4 were 0.77 +- 0.01 (substrate; maltose) and 0.78 +- 0.01 (substrate; sucrose), and those of ZnSO4 were 5.49 +- 0.14 (substrate; maltose) and 4.70 +- 0.06 (substrate; sucrose) for yeast alpha-glucosidase. | Copper Sulfate | sucrase isomaltase (alpha-glucosidase) | Mus musculus |
| 4 | On the basis of Lineweaver-Burk plots, both CuSO4 and ZnSO4 exhibited different modes of inhibition against alpha-glucosidase. | Copper Sulfate | sucrase isomaltase (alpha-glucosidase) | Mus musculus |
| 5 | These results indicate that CuSO4 suppresses disaccharide digestion by inhibiting alpha-glucosidase activity in the epithelium of the small intestine, suggesting that antidiabetic Cu complexes with some ligands have a similar action mechanism to that of alpha-glucosidase inhibitor, acarbose, currently used for clinical purposes. | Copper Sulfate | sucrase isomaltase (alpha-glucosidase) | Mus musculus |
| 6 | These results indicate that CuSO4 suppresses disaccharide digestion by inhibiting alpha-glucosidase activity in the epithelium of the small intestine, suggesting that antidiabetic Cu complexes with some ligands have a similar action mechanism to that of alpha-glucosidase inhibitor, acarbose, currently used for clinical purposes. | Copper Sulfate | sucrase isomaltase (alpha-glucosidase) | Mus musculus |