Title : Regulation of hippocampal long-term potentiation and long-term depression by diacylglycerol kinase ΞΆ.

Pub. Date : 2012 May

PMID : 21069783






2 Functional Relationships(s)
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1 DGKzeta, one of many mammalian DGKs, is localized to synapses through direct interaction with the postsynaptic scaffolding protein PSD-95, and regulates dendritic spine maintenance by promoting DAG-to-PA conversion. Phosphatidic Acids diacylglycerol kinase zeta Homo sapiens
2 These results suggest that DGKzeta regulates hippocampal LTP and LTD by promoting DAG-to-PA conversion, and establish that phospholipase C and protein kinase C lie upstream and downstream, respectively, of DGKzeta-dependent regulation of hippocampal LTP and LTD. Phosphatidic Acids diacylglycerol kinase zeta Homo sapiens