Title : Zinc-dependent effects of small molecules on the insulin-sensitive transcription factor FOXO1a and gluconeogenic genes.

Pub. Date : 2010 Mar

PMID : 21069157






1 Functional Relationships(s)
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1 The most potent compound tested on gluconeogenesis is disulfiram, which in the presence of 10 muM zinc, inhibited both PEPCK and G6Pase with an IC50 of 4 muM. Disulfiram phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens