Pub. Date : 2011 Jan
PMID : 21064165
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | p115-RhoGEF (p115) belongs to the family of RGS-containing guanine nucleotide exchange factors for Rho GTPases (RGS-RhoGEFs) that are activated by G12 class heterotrimeric G protein alpha subunits. | Guanine Nucleotides | paired like homeodomain 2 | Homo sapiens |
| 2 | p115-RhoGEF (p115) belongs to the family of RGS-containing guanine nucleotide exchange factors for Rho GTPases (RGS-RhoGEFs) that are activated by G12 class heterotrimeric G protein alpha subunits. | Guanine Nucleotides | paired like homeodomain 2 | Homo sapiens |
| 3 | We have identified that the linker region connecting the N-terminal RGS-homology (RH) domain and the DH domain inhibits the intrinsic guanine nucleotide exchange (GEF) activity of p115, and determined the crystal structures of the DH/PH domains in the presence or absence of the inhibitory linker region. | Guanine Nucleotides | paired like homeodomain 2 | Homo sapiens |