Title : GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension.

Pub. Date : 2010 Dec

PMID : 21059996






1 Functional Relationships(s)
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1 eNOS(-/-)/GCH(+/-) hybrid mice demonstrated that GTPCH preserved the circulating EPC number, reduced intracellular O2- in EPCs, and ameliorated EPC dysfunction independent of eNOS in DOCA-salt hypertension. Superoxides GTP cyclohydrolase 1 Mus musculus