Title : CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis.

Pub. Date : 2011 Feb

PMID : 21045201






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Combining the results of these four enzyme phenotyping approaches, we demonstrated that CYP4F2 and possibly other enzymes of the CYP4F subfamily (e.g., CYP4F3B) are the major enzymes responsible for the omega-hydroxylation of fingolimod, the main elimination pathway of the drug in vivo. Fingolimod Hydrochloride cytochrome P450 family 4 subfamily F member 2 Homo sapiens