Title : Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis.

Pub. Date : 2010 Nov 16

PMID : 21041628






2 Functional Relationships(s)
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1 We found that dietary sulindac induced apoptosis to remove the intestinal stem cells with nuclear or phosphorylated beta-catenin in APC(Min/+) mice. Sulindac catenin (cadherin associated protein), beta 1 Mus musculus
2 Furthermore, deficiency in SMAC, a mitochondrial apoptogenic protein, attenuated the tumor-suppressive effect of sulindac in APC(Min/+) mice by blocking apoptosis and removal of stem cells with nuclear or phosphorylated beta-catenin. Sulindac catenin (cadherin associated protein), beta 1 Mus musculus