Title : Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13.

Pub. Date : 2010 Nov 1

PMID : 21040544






1 Functional Relationships(s)
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1 RESULTS: Siglec-F deficient mice challenged with OVA for one month had significantly increased numbers of BAL and peribronchial eosinophils compared to WT mice which was associated with a significant increase in mucus expression as assessed by the number of periodic acid Schiff positive airway epithelial cells. Periodic Acid sialic acid binding Ig-like lectin F Mus musculus