Pub. Date : 2010 Dec
PMID : 21039523
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GAD65 is essential for synthesis of GABA destined for tonic inhibition regulating epileptiform activity. | gamma-Aminobutyric Acid | glutamic acid decarboxylase 2 | Mus musculus |
| 2 | GABA is synthesized from glutamate by glutamate decarboxylase (GAD), which exists in two isoforms, that is, GAD65 and GAD67. | gamma-Aminobutyric Acid | glutamic acid decarboxylase 2 | Mus musculus |
| 3 | In contrast, the functional significance of GAD65 in the maintenance of GABA destined for extrasynaptic tonic inhibition is less well studied. | gamma-Aminobutyric Acid | glutamic acid decarboxylase 2 | Mus musculus |
| 4 | An impaired tonic inhibition in GAD65-/- mice was revealed demonstrating a significant role of GAD65 in the synthesis of GABA acting extrasynaptically. | gamma-Aminobutyric Acid | glutamic acid decarboxylase 2 | Mus musculus |
| 5 | An impaired tonic inhibition in GAD65-/- mice was revealed demonstrating a significant role of GAD65 in the synthesis of GABA acting extrasynaptically. | gamma-Aminobutyric Acid | glutamic acid decarboxylase 2 | Mus musculus |
| 6 | The correlation between an altered tonic inhibition and metabolic events as well as the functional and metabolic role of GABA synthesized by GAD65 was further investigated in vivo. | gamma-Aminobutyric Acid | glutamic acid decarboxylase 2 | Mus musculus |
| 7 | Tonic inhibition and the demand for biosynthesis of GABA were augmented by injection of kainate into GAD65-/- and GAD65+/+ mice. | gamma-Aminobutyric Acid | glutamic acid decarboxylase 2 | Mus musculus |
| 8 | Tonic inhibition and the demand for biosynthesis of GABA were augmented by injection of kainate into GAD65-/- and GAD65+/+ mice. | gamma-Aminobutyric Acid | glutamic acid decarboxylase 2 | Mus musculus |
| 9 | These findings underline the importance of GAD65 for synthesis of GABA destined for extrasynaptic tonic inhibition, regulating epileptiform activity. | gamma-Aminobutyric Acid | glutamic acid decarboxylase 2 | Mus musculus |