Title : Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.

Pub. Date : 2010 Oct 20

PMID : 20962236






1 Functional Relationships(s)
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1 Tat-increased PM DAT and calpain activity are blocked by the RyR antagonists ryanodine and dantrolene, the calpain inhibitor calpastatin, and by a specific inhibitor of GSK-3beta. Ryanodine solute carrier family 6 member 3 Homo sapiens