Title : Basal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cells.

Pub. Date : 2010 Nov 1

PMID : 20959481






1 Functional Relationships(s)
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1 AZD6244 is a selective MEK1/2 inhibitor that markedly reduces tumor P-MAPK levels, but it produces few clinical responses in melanoma patients. AZD 6244 mitogen-activated protein kinase kinase 1 Homo sapiens