Title : The role of the breast cancer resistance protein (ABCG2) in the distribution of sorafenib to the brain.

Pub. Date : 2011 Jan

PMID : 20952483






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Sorafenib inhibited P-gp, but did not seem to be a P-gp substrate in vitro. Sorafenib phosphoglycolate phosphatase Mus musculus
2 This study shows that BCRP and P-gp together restrict the brain distribution of sorafenib with BCRP playing a dominant role in the efflux of sorafenib at the BBB. Sorafenib phosphoglycolate phosphatase Mus musculus