Title : A sol-gel-derived acetylcholinesterase microarray for nanovolume small-molecule screening.

Pub. Date : 2010 Nov 15

PMID : 20949898






1 Functional Relationships(s)
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1 The assay is based on a disulfide-thiol interchange reaction between the intramolecularly quenched dimeric dye BODIPY FL l-cystine and thiocholine generated by the AChE-catalyzed hydrolysis of acetylthiocholine (ATCh), which results in a brightly fluorescent monomeric product owing to the cleavage of the disulfide-coupled form of the dye. Sulfhydryl Compounds acetylcholinesterase (Cartwright blood group) Homo sapiens