Title : A novel defect in mitochondrial p53 accumulation following DNA damage confers apoptosis resistance in Ataxia Telangiectasia and Nijmegen Breakage Syndrome T-cells.

Pub. Date : 2010 Nov 10

PMID : 20947454






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We have previously shown that whereas T-cells from normal individuals undergo accumulation of p53 and apoptosis when treated with the genotoxic agent Actinomycin D (ActD), those from Ataxia Telangiectasia (AT) and Nijmegen Breakage Syndrome (NBS) patients resist ActD-induced apoptosis [1]. Dactinomycin tumor protein p53 Homo sapiens