Pub. Date : 2010 Nov
PMID : 20943306
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thermodynamics of radicicol binding to human Hsp90 alpha and beta isoforms. | monorden | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 2 | Radicicol is a natural antibiotic that specifically inhibits chaperone Hsp90 activity and binds to its active site with nanomolar affinity. | monorden | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 3 | Here we present a detailed thermodynamic description of radicicol binding to human Hsp90 and yeast Hsc82 studied by isothermal titration calorimetry and thermal shift assay. | monorden | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 4 | The intrinsic enthalpy of radicicol binding to Hsc82 was -46.7 kJ/mol, to Hsp90alpha -70.7 kJ/mol, and to Hsp90beta was -66.8 kJ/mol. | monorden | heat shock protein 90 alpha family class A member 1 | Homo sapiens |