Title : [Visualization of amyloid formation processes on cell membranes: gangliosides as key molecules for the onset of amyloidosis].

Pub. Date : 2010 Oct

PMID : 20930481






2 Functional Relationships(s)
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1 Abeta was accumulated on cholesterol-dependent ganglioside-rich domains in PC12 neuronal cells in a time- and concentration-dependent manner, leading to cell death. Gangliosides amyloid beta precursor protein Rattus norvegicus
2 Nerve growth factor-induced differentiation of PC12 cells increased both gangliosides and cholesterol and thereby greatly potentiated the accumulation and cytotoxic effect of Abeta. Gangliosides amyloid beta precursor protein Rattus norvegicus