Title : hCG-induced down-regulation of PPARĪ³ and liver X receptors promotes periovulatory progesterone synthesis by macaque granulosa cells.

Pub. Date : 2010 Dec

PMID : 20926582






2 Functional Relationships(s)
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1 These data suggest that an initial action of LH/CG on the primate preovulatory follicle is to rapidly reduce the expression of PPARG, resulting in reduced NR1H3 with the consequence shifting the balance from cholesterol efflux via ABCA1 and ABCG1 to cholesterol uptake (SCARB1) and metabolism (STAR, P450 side-chain cleavage A1, hydroxysteroid dehydrogenase 3B). Cholesterol hypertrichosis 2 (generalised, congenital) Homo sapiens
2 These data suggest that an initial action of LH/CG on the primate preovulatory follicle is to rapidly reduce the expression of PPARG, resulting in reduced NR1H3 with the consequence shifting the balance from cholesterol efflux via ABCA1 and ABCG1 to cholesterol uptake (SCARB1) and metabolism (STAR, P450 side-chain cleavage A1, hydroxysteroid dehydrogenase 3B). Cholesterol hypertrichosis 2 (generalised, congenital) Homo sapiens