Pub. Date : 2010 Oct 28
PMID : 20925360
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sterol binding and membrane lipid attachment to the Osh4 protein of yeast. | Sterols | oxysterol-binding protein KES1 | Saccharomyces cerevisiae S288C |
| 2 | Osh4 is an oxysterol-binding protein homologue found in yeast that is essential for the intracellular transport of sterols and cell life. | Sterols | oxysterol-binding protein KES1 | Saccharomyces cerevisiae S288C |
| 3 | The binding energies between both sterols and Osh4 were dominated by van der Waals interactions with residues within the sterol binding pocket, and were further stabilized by water-mediated interactions with polar residues at the bottom of the binding pocket (W46, Q96, Y97, N165, Q181). | Sterols | oxysterol-binding protein KES1 | Saccharomyces cerevisiae S288C |
| 4 | Ultimately, understanding how Osh4 attaches to cellular membranes and binds sterol will lead to a clear understanding of how this protein transports sterols between organelles in vivo. | Sterols | oxysterol-binding protein KES1 | Saccharomyces cerevisiae S288C |
| 5 | Ultimately, understanding how Osh4 attaches to cellular membranes and binds sterol will lead to a clear understanding of how this protein transports sterols between organelles in vivo. | Sterols | oxysterol-binding protein KES1 | Saccharomyces cerevisiae S288C |