Title : Possible involvement of intracellular angiotensin II receptor in high-glucose-induced damage in renal proximal tubular cells.

Pub. Date : 2011 Mar-Apr

PMID : 20890878






2 Functional Relationships(s)
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1 RESULTS: High-glucose treatment (4x10-2 mol/L) significantly increased NAG release, angiotensin II concentrations in cell lysates and 8-OHdG and p22phox protein levels compared with those in regular glucose medium (1.75x10(-2) mol/L). Glucose cytochrome b-245 alpha chain Homo sapiens
2 ARBs (candesartan, olmesartan or valsartan; 1x10(-9)-10(-7) mol/L) showed a significant reduction in high-glucose-induced NAG, 8-OHdG and p22phox protein levels in RPTECs. Glucose cytochrome b-245 alpha chain Homo sapiens