Pub. Date : 2010 Sep 27
PMID : 20885957
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In addition, we found that transfection of constitutively active AKT up-regulated p-Thr32-FOXO3a and p-Ser253-FOXO3a expression and inhibited AZD6244-induced Bim expression in sensitive cells. | AZD 6244 | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | These results show that Bim plays an important role in AZD6244-induced apoptosis in lung cancer cells and that the PI3K/AKT/FOXO3a pathway is involved in Bim regulation and susceptibility of lung cancer cells to AZD6244. | AZD 6244 | AKT serine/threonine kinase 1 | Homo sapiens |