Title : Glucocorticoid-induced impairment of mammary gland involution is associated with STAT5 and STAT3 signaling modulation.

Pub. Date : 2010 Dec

PMID : 20881248






4 Functional Relationships(s)
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1 Our results show that the synthetic glucocorticoid dexamethasone (DEX) modulates STAT5A and STAT3 signaling and inhibits apoptosis induction in postlactating mouse mammary glands, only when administered within the first 48 h upon cessation of suckling. Dexamethasone signal transducer and activator of transcription 3 Mus musculus
2 Our results show that the synthetic glucocorticoid dexamethasone (DEX) modulates STAT5A and STAT3 signaling and inhibits apoptosis induction in postlactating mouse mammary glands, only when administered within the first 48 h upon cessation of suckling. Dexamethasone signal transducer and activator of transcription 3 Mus musculus
3 Moreover, DEX administration delayed STAT3 activation and translocation into epithelial cells nuclei. Dexamethasone signal transducer and activator of transcription 3 Mus musculus
4 In particular, DEX treatment impaired the increment in gene expression of signal transducer subunit gp130, normally up-regulated from lactation to involution and responsible for STAT3 activation. Dexamethasone signal transducer and activator of transcription 3 Mus musculus