Pub. Date : 2010 Dec
PMID : 20881248
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our results show that the synthetic glucocorticoid dexamethasone (DEX) modulates STAT5A and STAT3 signaling and inhibits apoptosis induction in postlactating mouse mammary glands, only when administered within the first 48 h upon cessation of suckling. | Dexamethasone | signal transducer and activator of transcription 3 | Mus musculus |
| 2 | Our results show that the synthetic glucocorticoid dexamethasone (DEX) modulates STAT5A and STAT3 signaling and inhibits apoptosis induction in postlactating mouse mammary glands, only when administered within the first 48 h upon cessation of suckling. | Dexamethasone | signal transducer and activator of transcription 3 | Mus musculus |
| 3 | Moreover, DEX administration delayed STAT3 activation and translocation into epithelial cells nuclei. | Dexamethasone | signal transducer and activator of transcription 3 | Mus musculus |
| 4 | In particular, DEX treatment impaired the increment in gene expression of signal transducer subunit gp130, normally up-regulated from lactation to involution and responsible for STAT3 activation. | Dexamethasone | signal transducer and activator of transcription 3 | Mus musculus |