Title : Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding.

Pub. Date : 2010 Dec

PMID : 20878668






2 Functional Relationships(s)
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1 Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding. Cysteine tumor protein p53 Homo sapiens
2 We have discovered ligands containing an alpha,beta-unsaturated double bond, characteristic of Michael acceptors, that bind covalently to generic cysteine sites in the p53 core domain. Cysteine tumor protein p53 Homo sapiens