Pub. Date : 2010 Nov
PMID : 20861238
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Hypothalamic paraventricular nucleus G alpha q subunit protein pathways mediate vasopressin dysregulation and fluid retention in salt-sensitive rats. | Salts | arginine vasopressin | Rattus norvegicus |
2 | In salt-challenged (21 d) DSS rats, acute oligodeoxynucleotide-mediated down-regulation of central Galphaq proteins returned plasma vasopressin to control levels (P < 0.05), decreased salt-induced water retention (P < 0.05), and restored the profound diuretic responses to pharmacological and physiological stimuli (P < 0.05). | Salts | arginine vasopressin | Rattus norvegicus |
3 | Therefore, the down-regulation of PVN Galphaq proteins plays a critical counter-regulatory role in preventing vasopressin hypersecretion in salt-resistant phenotypes and may represent a new therapeutic target in pathophysiological states featuring vasopressin dysregulation. | Salts | arginine vasopressin | Rattus norvegicus |