Title : Hypothalamic paraventricular nucleus G alpha q subunit protein pathways mediate vasopressin dysregulation and fluid retention in salt-sensitive rats.

Pub. Date : 2010 Nov

PMID : 20861238






3 Functional Relationships(s)
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1 Hypothalamic paraventricular nucleus G alpha q subunit protein pathways mediate vasopressin dysregulation and fluid retention in salt-sensitive rats. Salts arginine vasopressin Rattus norvegicus
2 In salt-challenged (21 d) DSS rats, acute oligodeoxynucleotide-mediated down-regulation of central Galphaq proteins returned plasma vasopressin to control levels (P < 0.05), decreased salt-induced water retention (P < 0.05), and restored the profound diuretic responses to pharmacological and physiological stimuli (P < 0.05). Salts arginine vasopressin Rattus norvegicus
3 Therefore, the down-regulation of PVN Galphaq proteins plays a critical counter-regulatory role in preventing vasopressin hypersecretion in salt-resistant phenotypes and may represent a new therapeutic target in pathophysiological states featuring vasopressin dysregulation. Salts arginine vasopressin Rattus norvegicus