Pub. Date : 2010 Nov
PMID : 20851815
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Parallel increase in community use of fosfomycin and resistance to fosfomycin in extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli. | Fosfomycin | EsbL | Escherichia coli |
| 2 | Parallel increase in community use of fosfomycin and resistance to fosfomycin in extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli. | Fosfomycin | EsbL | Escherichia coli |
| 3 | OBJECTIVES: To document fosfomycin susceptibility of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC), analyse trends in fosfomycin use and investigate fosfomycin resistance in ESBL-EC isolated from urinary tract infections (UTIs). | Fosfomycin | EsbL | Escherichia coli |
| 4 | In addition, the trend in fosfomycin resistance among ESBL-EC causing UTIs was determined in 9 of the 27 hospitals. | Fosfomycin | EsbL | Escherichia coli |
| 5 | The overall rate of fosfomycin resistance was 9.1%, but varied according to ESBL type (5.6% of CTX-M-14 isolates, 5.1% of SHV-12 and 15.3% of CTX-M-15). | Fosfomycin | EsbL | Escherichia coli |
| 6 | Predictors of infection with fosfomycin-resistant ESBL-EC were O25b/phylogroup B2 isolates, female gender and nursing home residence. | Fosfomycin | EsbL | Escherichia coli |
| 7 | CONCLUSIONS: Key factors related to increased fosfomycin resistance in ESBL-EC causing UTIs could be the rapid growth in community use of fosfomycin, the widespread distribution of the 025b/B2 E. coli clone and the existence of a susceptible population comprising women residing in nursing home facilities. | Fosfomycin | EsbL | Escherichia coli |
| 8 | CONCLUSIONS: Key factors related to increased fosfomycin resistance in ESBL-EC causing UTIs could be the rapid growth in community use of fosfomycin, the widespread distribution of the 025b/B2 E. coli clone and the existence of a susceptible population comprising women residing in nursing home facilities. | Fosfomycin | EsbL | Escherichia coli |