Title : An MHC-defined primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching.

Pub. Date : 2010 Nov

PMID : 20849552






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1 In this study, we used a novel MHC-defined rhesus macaque model to examine the impact of MHC matching on the stability of costimulation blockade-/sirolimus-mediated chimerism, and to probe possible mechanisms of bone marrow rejection after nonmyeloablative transplant. Sirolimus major histocompatibility complex, class I, C Homo sapiens