Title : Histidine residues in the Na+-coupled ascorbic acid transporter-2 (SVCT2) are central regulators of SVCT2 function, modulating pH sensitivity, transporter kinetics, Na+ cooperativity, conformational stability, and subcellular localization.

Pub. Date : 2010 Nov 19

PMID : 20843809






1 Functional Relationships(s)
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1 We used site-directed mutagenesis and treatment with diethylpyrocarbonate to identify histidine residues responsible for SVCT2 pH sensitivity. Diethyl Pyrocarbonate solute carrier family 23 member 2 Homo sapiens