Pub. Date : 2010 Nov 19
PMID : 20843809
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Histidine residues in the Na+-coupled ascorbic acid transporter-2 (SVCT2) are central regulators of SVCT2 function, modulating pH sensitivity, transporter kinetics, Na+ cooperativity, conformational stability, and subcellular localization. | Histidine | solute carrier family 23 member 2 | Homo sapiens |
| 2 | Histidine residues in the Na+-coupled ascorbic acid transporter-2 (SVCT2) are central regulators of SVCT2 function, modulating pH sensitivity, transporter kinetics, Na+ cooperativity, conformational stability, and subcellular localization. | Histidine | solute carrier family 23 member 2 | Homo sapiens |
| 3 | SVCT2 contains six histidine residues in its primary sequence, three of which are exofacial in the transporter secondary structure model. | Histidine | solute carrier family 23 member 2 | Homo sapiens |
| 4 | We used site-directed mutagenesis and treatment with diethylpyrocarbonate to identify histidine residues responsible for SVCT2 pH sensitivity. | Histidine | solute carrier family 23 member 2 | Homo sapiens |
| 5 | We conclude that five histidine residues, His(109), His(203), His(206), His(269), and His(413), are central regulators of SVCT2 function, participating to different degrees in modulating pH sensitivity, transporter kinetics, Na(+) cooperativity, conformational stability, and subcellular localization. | Histidine | solute carrier family 23 member 2 | Homo sapiens |
| 6 | We conclude that five histidine residues, His(109), His(203), His(206), His(269), and His(413), are central regulators of SVCT2 function, participating to different degrees in modulating pH sensitivity, transporter kinetics, Na(+) cooperativity, conformational stability, and subcellular localization. | Histidine | solute carrier family 23 member 2 | Homo sapiens |
| 7 | We conclude that five histidine residues, His(109), His(203), His(206), His(269), and His(413), are central regulators of SVCT2 function, participating to different degrees in modulating pH sensitivity, transporter kinetics, Na(+) cooperativity, conformational stability, and subcellular localization. | Histidine | solute carrier family 23 member 2 | Homo sapiens |
| 8 | We conclude that five histidine residues, His(109), His(203), His(206), His(269), and His(413), are central regulators of SVCT2 function, participating to different degrees in modulating pH sensitivity, transporter kinetics, Na(+) cooperativity, conformational stability, and subcellular localization. | Histidine | solute carrier family 23 member 2 | Homo sapiens |
| 9 | We conclude that five histidine residues, His(109), His(203), His(206), His(269), and His(413), are central regulators of SVCT2 function, participating to different degrees in modulating pH sensitivity, transporter kinetics, Na(+) cooperativity, conformational stability, and subcellular localization. | Histidine | solute carrier family 23 member 2 | Homo sapiens |
| 10 | We conclude that five histidine residues, His(109), His(203), His(206), His(269), and His(413), are central regulators of SVCT2 function, participating to different degrees in modulating pH sensitivity, transporter kinetics, Na(+) cooperativity, conformational stability, and subcellular localization. | Histidine | solute carrier family 23 member 2 | Homo sapiens |
| 11 | Thus, histidine residues are central regulators of SVCT2 function. | Histidine | solute carrier family 23 member 2 | Homo sapiens |