Title : SHP-1 inhibits β-catenin function by inducing its degradation and interfering with its association with TATA-binding protein.

Pub. Date : 2011 Jan

PMID : 20840866






3 Functional Relationships(s)
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1 Moreover, ectopic expression of SHP-1 but not the inactive form of SHP-1 (C453S) inhibited src-induced tyrosine phosphorylation of beta-catenin on tyrosines 86 and 654. Tyrosine protein tyrosine phosphatase non-receptor type 6 Homo sapiens
2 Moreover, ectopic expression of SHP-1 but not the inactive form of SHP-1 (C453S) inhibited src-induced tyrosine phosphorylation of beta-catenin on tyrosines 86 and 654. Tyrosine protein tyrosine phosphatase non-receptor type 6 Homo sapiens
3 In conclusion, SHP-1 negatively regulates beta-catenin transcriptional activity i) by dephosphorylating beta-catenin on tyrosines 86 and 654, ii) by impairing its capacity to interact with the basal transcriptional factor TBP and iii) by promoting beta-catenin degradation in a GSK3beta-dependent manner. Tyrosine protein tyrosine phosphatase non-receptor type 6 Homo sapiens