Title : Probing mammalian spermine oxidase enzyme-substrate complex through molecular modeling, site-directed mutagenesis and biochemical characterization.

Pub. Date : 2011 Apr

PMID : 20839014






1 Functional Relationships(s)
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1 Results obtained indicate that SMO binds spermine in a similar conformation as that observed in the yeast polyamine oxidase FMS1-spermine complex and demonstrate a major role for residues His82 and Lys367 in substrate binding and catalysis. Spermine spermine oxidase Homo sapiens