Title : Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity.

Pub. Date : 2010 Sep 14

PMID : 20837928






2 Functional Relationships(s)
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1 In SVGs exposed to atorvastatin ex vivo, without exposure to LDL, basal and NADPH-stimulated O(2)( -) were significantly reduced (P<0.01 for both concentrations versus 0 mumol/L) in association with a striking reduction in Rac1 activation and 1 membrane-bound Rac1 and p67(phox) subunit. NADP Rac family small GTPase 1 Homo sapiens
2 In SVGs exposed to atorvastatin ex vivo, without exposure to LDL, basal and NADPH-stimulated O(2)( -) were significantly reduced (P<0.01 for both concentrations versus 0 mumol/L) in association with a striking reduction in Rac1 activation and 1 membrane-bound Rac1 and p67(phox) subunit. NADP Rac family small GTPase 1 Homo sapiens