Title : 5'-3'-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage.

Pub. Date : 2010 Oct 1

PMID : 20837656






4 Functional Relationships(s)
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Protein Name
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1 Short, single-strand oligonucleotides that target this 5"-3"-UTR base-pairing region blunt the binding of RPL26 to p53 mRNA in cells and reduce p53 induction and p53-mediated cell death after several different types of DNA damage and cellular stress. Oligonucleotides tumor protein p53 Homo sapiens
2 Short, single-strand oligonucleotides that target this 5"-3"-UTR base-pairing region blunt the binding of RPL26 to p53 mRNA in cells and reduce p53 induction and p53-mediated cell death after several different types of DNA damage and cellular stress. Oligonucleotides tumor protein p53 Homo sapiens
3 Short, single-strand oligonucleotides that target this 5"-3"-UTR base-pairing region blunt the binding of RPL26 to p53 mRNA in cells and reduce p53 induction and p53-mediated cell death after several different types of DNA damage and cellular stress. Oligonucleotides tumor protein p53 Homo sapiens
4 The ability to reduce stress induction of p53 with oligonucleotides or other small molecules has numerous potential therapeutic uses. Oligonucleotides tumor protein p53 Homo sapiens