Title : Redox regulation of guanylate cyclase and protein kinase G in vascular responses to hypoxia.

Pub. Date : 2010 Dec 31

PMID : 20831906






1 Functional Relationships(s)
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1 The production of cGMP by the soluble form of guanylate cyclase (sGC) in bovine pulmonary arteries (BPA) is controlled by cytosolic NADPH maintaining reduced thiol and heme sites on sGC needed for activation by NO, and the levels of Nox oxidase-derived superoxide and peroxide that influence pathways regulating sGC activity. Superoxides guanylate cyclase Bos taurus