Pub. Date : 2010 Nov-Dec
PMID : 20828828
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Syk is phosphorylated on a number of tyrosines following the binding of IgE/allergen complexes to FceRI receptors leading to initiation of inflammatory signaling via downstream enzymes and scaffolding proteins. | Tyrosine | spleen associated tyrosine kinase | Rattus norvegicus |
| 2 | We examined the kinases responsible for the phosphorylation of key Syk tyrosines in rat RBL-2H3 basophilic cells and bone marrow-derived mast cells (BMMCs). | Tyrosine | spleen associated tyrosine kinase | Rattus norvegicus |
| 3 | The phosphorylation of Syk tyrosine 346 was completely blocked by the novel Src family kinase inhibitor BIRA766, suggesting this tyrosine is a pure substrate for Src family kinases. | Tyrosine | spleen associated tyrosine kinase | Rattus norvegicus |
| 4 | The phosphorylation of Syk tyrosine 346 was completely blocked by the novel Src family kinase inhibitor BIRA766, suggesting this tyrosine is a pure substrate for Src family kinases. | Tyrosine | spleen associated tyrosine kinase | Rattus norvegicus |
| 5 | This was supported by the findings that kinase-dead (KD) Syk was efficiently phosphorylated on this tyrosine and that a specific Syk inhibitor BAY61-3606 was without effect. | Tyrosine | spleen associated tyrosine kinase | Rattus norvegicus |
| 6 | The phosphorylation of other Syk tyrosines 317, 342, 519 and 520 was reduced by Syk and Src family inhibitors, suggesting a role for auto- and trans-phosphorylation. | Tyrosine | spleen associated tyrosine kinase | Rattus norvegicus |
| 7 | The phosphorylation of other Syk tyrosines 317, 342, 519 and 520 was reduced by Syk and Src family inhibitors, suggesting a role for auto- and trans-phosphorylation. | Tyrosine | spleen associated tyrosine kinase | Rattus norvegicus |
| 8 | Lyn was the predominant Src family kinase expressed and activated in RBL-2H3 cells, meanwhile Lyn knockdown with a specific siRNA interfered with the phosphorylation of all Syk tyrosines and the Syk substrates SLP-76 and LAT. | Tyrosine | spleen associated tyrosine kinase | Rattus norvegicus |
| 9 | This study identifies the responsible kinases for the phosphorylation of key Syk tyrosines and the propagation of FceRI receptor mediated signal transduction in allergic responses. | Tyrosine | spleen associated tyrosine kinase | Rattus norvegicus |