Title : Pharmacological inhibition of TRPM4 hyperpolarizes vascular smooth muscle.

Pub. Date : 2010 Nov

PMID : 20826763






2 Functional Relationships(s)
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1 Patch-clamp electrophysiology revealed that 9-phenanthrol blocks native TRPM4 currents in freshly isolated smooth muscle cells in a concentration-dependent manner (IC(50) = 10.6 muM). 9-phenanthrol latexin Homo sapiens
2 Using intracellular microelectrodes to record smooth muscle membrane potential in isolated cerebral arteries pressurized to 70 mmHg, we found that 9-phenanthrol (30 muM) reversibly hyperpolarized the membrane from ~-40 mV to ~-70 mV. 9-phenanthrol latexin Homo sapiens