Title : Protective effect of quercitrin against hydrogen peroxide-induced dysfunction in osteoblastic MC3T3-E1 cells.

Pub. Date : 2012 Mar

PMID : 20822887






2 Functional Relationships(s)
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1 Pretreatment of quercitrin increased collagen content, alkaline phosphatase (ALP) activity, and calcium deposition of osteoblasts compared with H(2)O(2) treated cells and these effects were blocked by ERKs and p38 mitogen-activated protein kinases (MAPKs) inhibitors such as PD98059 and SB203580, respectively. quercitrin mitogen-activated protein kinase 14 Mus musculus
2 These suggest that quercitrin-induced protective effect against osteoblast dysfunction by oxidative stress is associated with increased activation of ERKs and p38 MAPK. quercitrin mitogen-activated protein kinase 14 Mus musculus