Pub. Date : 2010 Aug
PMID : 20818067
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of docetaxel on expression of eIF3a in human lung cancer A549 cell line. | Docetaxel | eukaryotic translation initiation factor 3 subunit J | Homo sapiens |
| 2 | OBJECTIVE: To explore the dose-dependent and time-dependent effect of docetaxel on the expression of mammalian eukaryotic initiation factor 3 subunit A (eIF3a) in lung cancer cell line. | Docetaxel | eukaryotic translation initiation factor 3 subunit J | Homo sapiens |
| 3 | When A549 cells were treated with high concentration of docetaxel (30 mug/L), the expression level of eIF3a mRNA tended to increase in a time-dependent manner. | Docetaxel | eukaryotic translation initiation factor 3 subunit J | Homo sapiens |
| 4 | CONCLUSION: Docetaxel could slightly increase the expression of eIF3a mRNA, and eIF3a does not regulate the expression of alpha-tubulin in A549 cells treated by docetaxel. | Docetaxel | eukaryotic translation initiation factor 3 subunit J | Homo sapiens |