Title : The role of constitutively activated STAT3 in B16 melanoma cells.

Pub. Date : 2010 Jan 1

PMID : 20814592






3 Functional Relationships(s)
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1 We report here that in murine B16 melanoma cells, which have been previously shown to express constitutively active STAT3, the expression of a mutant form of STAT3 with the canonical tyrosine phosphorylation site (residue 705) mutated to phenylanaine has dominant-negative properties (STAT3-DN). phenylanaine signal transducer and activator of transcription 3 Mus musculus
2 We report here that in murine B16 melanoma cells, which have been previously shown to express constitutively active STAT3, the expression of a mutant form of STAT3 with the canonical tyrosine phosphorylation site (residue 705) mutated to phenylanaine has dominant-negative properties (STAT3-DN). phenylanaine signal transducer and activator of transcription 3 Mus musculus
3 We report here that in murine B16 melanoma cells, which have been previously shown to express constitutively active STAT3, the expression of a mutant form of STAT3 with the canonical tyrosine phosphorylation site (residue 705) mutated to phenylanaine has dominant-negative properties (STAT3-DN). phenylanaine signal transducer and activator of transcription 3 Mus musculus