Title : Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis.

Pub. Date : 2011 Feb

PMID : 20805790






1 Functional Relationships(s)
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1 Both FASN inhibitors, cerulenin and orlistat, significantly reduced melanoma cell proliferation and activated the intrinsic pathway of apoptosis, as demonstrated by the cytochrome c release and caspase-9 and -3 activation. Cerulenin caspase 9 Mus musculus