Pub. Date : 2010 Nov
PMID : 20805360
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Polyamines regulate the stability of JunD mRNA by modulating the competitive binding of its 3" untranslated region to HuR and AUF1. | Polyamines | ELAV like RNA binding protein 1 | Homo sapiens |
| 2 | The depletion of cellular polyamines enhanced HuR binding to JunD mRNA and decreased the levels of JunD transcript associated with AUF1, thus stabilizing JunD mRNA. | Polyamines | ELAV like RNA binding protein 1 | Homo sapiens |
| 3 | The silencing of HuR increased AUF1 binding to the JunD mRNA, decreased the abundance of HuR-JunD mRNA complexes, rendered the JunD mRNA unstable, and prevented increases in JunD mRNA and protein in polyamine-deficient cells. | Polyamines | ELAV like RNA binding protein 1 | Homo sapiens |
| 4 | Conversely, increasing the cellular polyamines repressed JunD mRNA interaction with HuR and enhanced its association with AUF1, resulting in an inhibition of JunD expression. | Polyamines | ELAV like RNA binding protein 1 | Homo sapiens |
| 5 | These results indicate that polyamines modulate the stability of JunD mRNA in intestinal epithelial cells through HuR and AUF1 and provide new insight into the molecular functions of cellular polyamines. | Polyamines | ELAV like RNA binding protein 1 | Homo sapiens |