Title : Single-cell analysis of dihydroartemisinin-induced apoptosis through reactive oxygen species-mediated caspase-8 activation and mitochondrial pathway in ASTC-a-1 cells using fluorescence imaging techniques.

Pub. Date : 2010 Jul-Aug

PMID : 20799830






2 Functional Relationships(s)
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1 We have previously reported that DHA induced caspase-3-dependent apoptosis in human lung adenocarcinoma cells. artenimol caspase 3 Homo sapiens
2 Confocal imaging analysis in a single living cell and Western blot assay showed that DHA triggered ROS-dependent Bax translocation, mitochondrial membrane depolarization, alteration of mitochondrial morphology, cytochrome c release, caspase-9, caspase-8, and caspase-3 activation, indicating the coexistence of ROS-mediated mitochondrial and death receptor pathway. artenimol caspase 3 Homo sapiens